Can Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) occur after Covid 19 Infection?
- WPI
- 6 days ago
- 2 min read
Posted on:13th January 2025
Authors: Suzanne D Vernon, Tianyu Zheng, Hyungrok Do, Vincent C Marconi, Leonard A Jason, Nora G Singer, Benjamin H Natelson, Zaki A Sherif, Hector Fabio Bonilla, Emily Taylor, Janet M Mullington, Hassan Ashktorab, Adeyinka O Laiyemo, Hassan Brim, Thomas F Patterson, Teresa T Akintonwa, Anisha Sekar, Michael J Peluso, Nikita Maniar, Lucinda Bateman, Leora I Horwitz, Rachel Hess; NIH Researching COVID to Enhance Recovery (RECOVER) Consortium
PMID: 39804551
Abstract
Objective: To determine the incidence and prevalence of post-COVID-19 ME/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study.
Design, setting, and participants: RECOVER-Adult is a longitudinal observational cohort study conducted across the U.S. We included participants who had a study visit at least 6 months after infection and had no pre-existing ME/CFS, grouped as (1) acute infected, enrolled within 30 days of infection or enrolled as uninfected who became infected (n=4515); (2) post-acute infected, enrolled greater than 30 days after infection (n=7270); and (3) uninfected (1439).
Results: The incidence rate of ME/CFS in participants followed from time of SARS-CoV-2 infection was 2.66 (95% CI 2.63-2.70) per 100 person-years while the rate in matched uninfected participants was 0.93 (95% CI 0.91-10.95) per 100 person-years: a hazard ratio of 4.93 (95% CI 3.62-6.71). The proportion of all RECOVER-Adult participants that met criteria for ME/CFS following SARS-CoV-2 infection was 4.5% (531 of 11,785) compared to 0.6% (9 of 1439) in uninfected participants. Post-exertional malaise was the most common ME/CFS symptom in infected participants (24.0%, 2830 of 11,785). Most participants with post-COVID-19 ME/CFS also met RECOVER criteria for long COVID (88.7%, 471 of 531).
Limitations: The ME/CFS clinical diagnostic criteria uses self-reported symptoms. Symptoms can wax and wane.
Conclusion: ME/CFS is a diagnosable sequela that develops at an increased rate following SARS-CoV-2 infection. RECOVER provides an unprecedented opportunity to study post-COVID-19 ME/CFS.
The published journal article can be read on the https://pubmed.ncbi.nlm.nih.gov/39804551/
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